Composition : Tacrolimus
Indication: Prevention of graft rejection following transplantation of liver or kidney. Treatment of liver or kidney allograft rejection in patients previously having received other immunosuppressive agents.
Adult Liver transplantation: Initially 0.1-0.2 mg/kg/day in 2 divided doses.
Adult Kidney transplantation: Initially 0.15-0.3 mg/kg/day in 2 divided doses.
Pediatric Liver & Kidney transplantation: Initially 0.3 mg/kg/day in 2 divided doses.
Take on an empty stomach at least 1 hr before or 2-3 hr after meals.
Contraindication: Pregnancy. Hypersensitivity to tacrolimus or other macrolides.
Adverse Reactions: Infections, abnormal kidney function,hyperglycemia, DM, tremor, headache, paresthesia,HTN, ECG changes, tachycardia, peripheral edema, vasodilatation, anemia,coagulation disorders, thrombocytopenia,leucocytosis, leucopenia, pancytopenia,nausea, diarrhea, asthma.
Drug Interaction: Cyclosporine A.
Preparations: Cap 0.5mg x 5x 10's . 1 mg x 5 x 10's .