Composition : Tacrolimus

Indication: Prevention of graft rejection following transplantation of liver or kidney. Treatment of liver or kidney allograft rejection in patients previously having received

other immunosuppressive agents.

Dosage : Adult :Liver transplantation Initially 0.1-0.2 mg/kg/day in 2 divided doses.

Kidney transplantation: Initially 0.15-0.3 mg/kg/day in 2 divided doses

(morning & evening).Take on an empty stomach at least 1 hr before or 2-3 hr after meals.

Contraindication: Pregnancy. Hypersensitivity to

tacrolimus or other macrolides.

Adverse Reactions: Infections, abnormal kidney function,

hyperglycemia, DM, tremor, headache, paresthesia,HTN, ECG changes, tachycardia,

peripheral edema, vasodilatation, anemia,coagulation disorders, thrombocytopenia,

leucocytosis, leucopenia, pancytopenia,nausea, diarrhea, asthma.

Drug Interaction: Cyclosporine A.

Preparations: Cap 0.5mgx5x10's . 1 mg x 5 x 10's .



Komposisi: Tacrolimus